Not really sure how Cytron modify the UIC00B from PICkit 2, but I have try a few configurations. If you are using PICkit 2 Programmer standalone software, basically you can ignore the Vdd setting.
But if you are integrating with MPLAB IDE, you need to take care of that.
I think UIC00B do detect the target board Vdd/Vcc. If the Vdd pin is not connected to UIC00B (example SK40C), you need to make sure the option "Use Target Power Always" is not selected, else the MPLAB IDE will ensure the pin of Vdd/Vcc have 5V or 3.3V before loading program, which in SK40C case, it detect nothing as it is not connected.
Not really sure how SK18B, but you can check the schematic to make sure that.